An 8-year-old boy from a region in Africa where Human Herpesvirus 8 is endemic presents with aggressive, widespread cutaneous nodules and visceral involvement. A diagnosis of endemic Kaposi sarcoma is made. The pathogenesis of this and other HHV-8 associated lymphoproliferative disorders involves multiple virally-encoded proteins that manipulate host cell processes. Which of the following is a key pathogenic mechanism of HHV-8?