A 10-year-old boy with a history of severe systemic reactions to honeybee stings has positive venom-specific IgE testing. Basal tryptase is elevated. What factor increases his risk for relapse or treatment failure after completing venom immunotherapy?
A 13-year-old girl develops severe bilateral conjunctival redness, itching, and watery discharge each spring, with similar nasal symptoms. Which condition most likely explains her symptoms?
A 16-year-old with severe, chronic atopic dermatitis has failed topical therapies and phototherapy. Which medication directly targets IL-4 and IL-13 signaling?
A 9-year-old with asthma and peanut allergy experiences anaphylaxis 3 hours after eating red meat. He had multiple tick bites weeks earlier. Which allergen is most likely responsible?
An 8-year-old develops widespread, edematous, itchy lesions on the arms that resolve within hours after playing in tall grass. What is the most likely diagnosis?
An 11-year-old boy with known atopy presents with large, persistent local swelling (> 10 cm) and redness at the site of a yellowjacket sting lasting several days but no systemic symptoms. What is the best management strategy?
A 10-year-old has pruritic hives after receiving amoxicillin. This reaction lasts for 3 hours and resolves. Which class of hypersensitivity reaction is this?
A 14-year-old boy is evaluated after recurrent angioedema of hands and lips without urticaria. Which test will help confirm the diagnosis?
