A 16-month-old with recurrent persistent oral thrush since infancy is found to have a dominant-negative IL17F mutation. Which additional infection risk is likely in this child?
A 12-year-old with Common variable immunodeficiency and chronic respiratory infection is on immunoglobulin G replacement therapy (IgRT). What target serum IgG trough level is associated with decreased risk of pneumonia?
A 7-year-old is diagnosed with chronic mucocutaneous candidiasis and has a history of staphylococcal skin infections and normal lymphocyte phenotyping. Sequencing identifies biallelic mutations in a gene for a C-type lectin receptor adaptor. Which other phenotype is expected?
A child with relapsed lymphoma is being considered for autologous HSCT. Which statement is TRUE regarding autologous versus allogeneic transplantation?
A 10-year-old presents with central nervous system Candida albicans infection and necrotizing granulomatous inflammation on biopsy. Which finding is most likely on laboratory review?
An 18-month-old infant has a history of recurrent invasive pneumococcal infections. What underlying immune mechanism is most likely deficient in this patient?
A 3-year-old with recurrent sinopulmonary infections presents with suspected primary immune deficiency disease. Which of the following infection patterns is a typical presentation of primary immune deficiency diseases?
A 5-year-old is suspected to have a B-cell defect. Which of the following clinical findings is MOST suggestive of humoral immunodeficiency?
A 10-year-old is evaluated for possible immunodeficiency due to recurrent infections. A key physical exam finding suggestive of X-linked agammaglobulinemia is?
A 3-year-old with recurrent infections is suspected of macrophage dysfunction. Which infection would increase your suspicion?
