A term newborn presents on day 3 with persistent hypoglycemia despite regular feeds. He was born to a mother with poorly controlled gestational diabetes. Which pathophysiologic mechanism explains the hypoglycemia?
A 32-week infant develops pulmonary hemorrhage requiring intensive support. Which medication, if given prophylactically, could have reduced this risk?
A term neonate is evaluated for microcephaly, cataracts, “blueberry muffin” skin lesions, and cardiac murmurs. Which infection is most likely?
An infant with complicated meconium ileus presents with radiographic evidence of intra-abdominal calcification, mass effect, and peritoneal fluid. What is the diagnosis?
A 12-hour-old term infant is found to have a single umbilical artery on physical exam. What is the next best step?
A very low birthweight neonate develops necrotizing enterocolitis with worsening clinical status despite optimal medical management. Which is an absolute indication for surgery?
A mother reports a family history of hemolytic anemia. Her neonate, presenting with significant jaundice, has microspherocytes on peripheral smear and a negative direct antiglobulin test. Which genetic abnormality is likely?
A well-appearing breastfed term infant shows total serum bilirubin of 22 mg/dL on day 10, with indirect fraction 21.6 mg/dL and normal labs. The infant is feeding well, no anemia or hemolysis. What is the most likely diagnosis?
A 1-week-old term neonate presents with jaundice, hepatosplenomegaly, and a microcephaly. Initial investigations reveal periventricular calcifications on imaging and positive urine cytomegalovirus polymerase chain reaction. What long-term complication is the infant most at risk for?
A neonate born to a young mother presents with abdominal wall herniation, eviscerated bowel not covered by a peritoneal sac. Which additional risk is most associated with this condition?
